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cannabis will increase the stage or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.Keep an eye on Intently (1)mitotane decreases levels of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Mitotane is a robust inducer of cytochrome P-4503A4; watch when